Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites ...

Objective Hepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this ...

Division of Hepatology and Metabolism, Department of Internal Medicine, Saga Medical School, Saga, Japan Dr I Ozaki, Division of Hepatology and Metabolism, Department of Internal Medicine, Saga ...

1 Dalhousie Inflammation Group and Department of Pediatrics, and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada 2 Dalhousie Inflammation Group and ...

Objective To appraise the evidence that pathophysiological mechanisms and individualised treatment directed at those mechanisms provide an alternative approach to the treatment of patients with ...

2 Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China Background Tumourigenesis in right-sided and left-sided colons demonstrated ...

Correspondence to Dr Barham K Abu Dayyeh, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R), Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, ...

1 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Greenebaum Cancer Center, Baltimore, Maryland, USA 2 Division of Gastroenterology and Hepatology, ...

Objective To determine whether proton pump inhibitors (PPIs) are associated with an increased risk of colorectal cancer, compared with histamine-2 receptor antagonists (H2RAs). Design The United ...

1 Cancer Research UK Colorectal Cancer Unit, St Mark’s Hospital, Harrow, Middlesex HA1 3UJ, UK 2 Wolfson Unit for Endoscopy, St Mark’s Hospital Most colon cancers are assumed to have a premalignant ...

2 Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham General Hospital, Cheltenham, UK 3 Department of Gastroenterology, Gloucestershire Hospitals NHS Foundation ...

Intestinal permeability was estimated in healthy subjects after ingestion of aspirin (1.2+1.2 g), ibuprofen (400+400 mg) and indomethacin (75+50 mg) at midnight and an hour before starting a ...