The San Francisco 49ers (6-10) are 4.5-point underdogs as they try to break their three-game losing streak in a matchup against the Arizona Cardinals (7-9) on Sunday, January 5, 2025 at State Farm

The Los Angeles Rams (9-6) will try to extend their four-game winning streak when they host the Arizona Cardinals (7-8) in an NFC West battle on Saturday. Los Angeles has won eight of its last 10 games to take a half-game lead over Seattle atop the division standings.

Week 18 is under way as the Baltimore Ravens clinched the AFC North on Saturday while the Pittsburgh Steelers lost their fourth in a row, allowing the Cincinnati Bengals to keep their slim playoff hopes alive.