Overview Name: Synonyms: LY2062430 Therapy Type: Immunotherapy (passive) (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: Eli Lilly & Co. Approved for: None Background Solanezumab is a humanized monoclonal IgG1 antibody directed against the mid-domain of the Aβ peptide. It recognizes soluble monomeric, not fibrillar, Aβ. The ...

AlzAntibodies This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease. AlzBiomarker This interactive database captures two decades of research on fluid biomarkers for Alzheimer's disease. Curated measurements and related data from peer-reviewed articles are presented, as well as meta-analyses for selected biomarkers. This ...

3 days ago · Could treating Alzheimer’s disease be as simple as inhaling xenon? Data from mice support this provocative idea. Huffing xenon for 40 minutes weekly shifted microglia from pro-inflammatory to phagocytic, allowing these immune cells to better corral plaques and prevent neurite degeneration. A Phase 1 trial in healthy elderly volunteers has started.

07 Jun 2013 Brain atrophy plagues more than just people with neurodegenerative disorders. Even seemingly healthy individuals lose brain matter over time. Can doctors and researchers separate brain changes due to Alzheimer's disease and other dementias from those caused by normal aging, and if so, which brain regions offer the clearest and earliest signs of disease? Two recent papers illustrate ...

Oct 9, 2023 · Overview Name: Synonyms: Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® Chemical Name: 3, 5-Dimethyl-1-adamantanamine hydrochloride Therapy Type: Small Molecule (timeline) Target Type: Other Neurotransmitters (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: Forest Laboratories, Inc., Lundbeck, Merz Pharma Approved for: Alzheimer's Disease Background Memantine is ...

23 Dec 2024 Dear Scott, Thanks for your kind comments and for posing an important question for debate (see 20 Dec Open Letter). Your choice of “Open Letter” to one individual is a bit whimsical, a first for me. I’m not sure why you singled me out, but I accept the debate in the positive spirit you conveyed. I view your topic as distinct from the Perspective that 12 of us wrote for ...

May 16, 2023 · Overview Name: Donepezil Synonyms: Aricept™, Donepezil hydrochloride, Eranz®, E 2020 Chemical Name: 2- [ (1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one Therapy Type: Small Molecule (timeline) Target Type: Cholinergic System (timeline) Condition (s): Alzheimer's Disease, Dementia with Lewy Bodies, Down's Syndrome, Parkinson's Disease Dementia U.S. FDA Status: Alzheimer ...

Jan 16, 2018 · 12 Jan 2006 The drug memantine is a safe and effective therapy that helps patients suffering from moderate to severe Alzheimer disease for up to a year. However, evidence that the drug might slow the underlying pathology is weak. These are the two main conclusions of a 24-week, open-label extension of a 28-week, randomized clinical trial. Open-label extension allows patients who were ...

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APP APP encodes amyloid precursor protein, a transmembrane protein which is cleaved to form amyloidogenic Aβ peptides. Mutations in APP are associated with familial forms of early onset Alzheimer's disease as well as with Cerebral Amyloid Angiopathy (CAA). Pathogenic mutations generally alter processing by secretases, leading in an overall increase in Aβ production and/or a change in the ...